Coronavirus continues to move relentlessly throughout the world, with isolation and suffering as its unwelcome companions. The impact is being felt by individuals, families, communities, and nations. Lives and livelihoods have been lost, and no person is unaffected. Medically vulnerable people, members of underrepresented groups, essential workers, and health care professionals have for months been carrying more than their share of risk and burden due to the infection. Inadequate, maldistributed health and economic resources are widening existing health and societal disparities. Hundreds of thousands of people have succumbed to COVID-19 during the opening wave of the global pandemic.